Acquired Sensitivity to para-Aminosalicylic Acid

Para-Aminosalicylic Acid: Pas

Toleration and absorption of sodium para-aminosalicylate and para-aminosalicylic acid (neopasalate). Comparison with other forms of para-aminosalicylic acid.

Lymphoma-like syndrome following para-aminosalicylic acid.

This report describes a patient who developed a Hodgkin's disease-like picture both clinically and pathologically, following the administration of para-aminosalicylic acid, with complete regression on cessation of therapy.

Comparison of solid and liquid medium sensitivity tests of tubercle bacilli to para-aminosalicylic acid.

In the treatment of tuberculosis para-aminosalicylic acid (P.A.S.) is now chiefly used in combination with streptomycin or isoniazid with the aim of preventing or delaying the emergence of drug-resistant strains of tubercle bacilli (Medical Research Council, 1950, 1953c). Such combined therapy is only effective in preventing drug resistance when the strains obtained before the start of treatmen...

The in Vitro Effect of Para-aminosalicylic Acid (pas) in Preventing Acquired Resistance to Streptomycin by Mycobacterium Tuberculosis.

Streptomycin was reported as being bacteriostatic and moderately bactericidal for Mycobacterium tuerculo8s by Schatz and Waksman (1944). These results were confirmed and extended by Youmans (1945), who reported that the drug was bacteriostatic at concentrations of 0.095 to 0.28 units per ml and bactericidal at concentrations in excess of 50 units per ml. Additional confirmatory observations hav...